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Buserelin Stat

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10 mL vial

Each milliliter contains 4.2 mg of buserelin acetate, equivalent to 8 mg of acetate.

Gonadotropin-releasing hormone (GnRH) is secreted by the hypothalamus and transported to the pituitary gland via the portal venous circulation. In the anterior pituitary, GnRH stimulates the increased secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which promote corpus luteum formation in females and spermatogenesis in males. The released LH and FSH lead to rapid follicular growth, maturation, and subsequent ovulation.

Cattle:

Increased fertility rate (at the time of insemination)

Ovarian cysts (follicular)

Ovulation disorders in dairy cows

Anestrus

Estrus synchronization using prostaglandins and control of ovulation timing

Mare:

Anestrus

Increased fertility rate

Ovulation disorders

Precise control of ovulation timing

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Cattle: 2.5 – 5 mL, equivalent to 10–20 micrograms of buserelin, administered as a single intramuscular injection.

Mare: 5 – 10 mL, equivalent to 20–40 micrograms of buserelin, administered intramuscularly in one or two injections.

This drug can also be administered intravenously or subcutaneously; however, to avoid reactions and hypersensitivity in the animal, intramuscular injection is generally recommended.

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Concurrent use with other hormonal drugs such as progesterone or estrogens may alter the effect of buserelin.
Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the body’s response to buserelin.
Immunosuppressive drugs may weaken the therapeutic effect of buserelin.
Concurrent use with other drugs affecting the hypothalamic-pituitary-ovarian axis should be done under veterinary supervision.