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ویال دی کلو پروستنول

D-Cloprostenol

Type of medicine

,

Target species

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Packaging

Vials of 10 ml and 20 ml.

Compounds

Each milliliter contains 0.075 mg of D-cloprostenol sodium.

Mechanism of the Effect

D-Cloprostenol Sodium is a synthetic analogue of prostaglandin F2α and possesses all its biological effects. D-Clo PG induces contraction of the myometrium, relaxation of the cervix, and reduction of uterine volume. Upon acting on a mature corpus luteum, it causes its regression both scientifically and morphologically. (This action results in estrus in the animal within 2 to 5 days after injection).

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Use case

D-Clo PG (D-Cloprostenol Sodium) is suitable for use in horses and cattle.

In cattle, D-Clo PG is used for the following purposes:

Regression of the corpus luteum, followed by ovulation and onset of estrus in non-pregnant dairy cows with active ovaries

Use in estrus synchronization programs along with GnRH analogs

Treatment of chronic ovarian tumors or luteal cysts

Endometritis treatment

Increasing the strength of uterine myometrial contractions

Induction of abortion and termination of pregnancy

Treatment of uterine infections

Managing uterine disorders and complications after calving

Treatment of silent heat (hidden estrus) cases

The amount and how to use

D-Clo PG is administered by intramuscular injection.

Cattle: 2 milliliters

Horses: 1 milliliter

Caution

Use with caution in the treatment of pyometra if the cervix is closed, as there is a risk of peritonitis due to uterine rupture.

PGF2α is absorbed through the skin; therefore, pregnant women and individuals with asthma should handle it carefully due to the risk of bronchial spasms.

In case of contact, wash the affected area thoroughly with soap and water and use bronchodilator medications if needed.

In horses, side effects may include sweating, increased heart rate, and abdominal pain.

These drugs are expected to be effective in animals with an active corpus luteum.

Drug interference

Concurrent use with non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the effect of prostaglandins.

Simultaneous administration with prostaglandin antagonists can diminish the effect of d-cloprostenol.

Co-administration with hormonal or reproductive drugs should be done under veterinary supervision.

Maintenance conditions

The medication should be stored at a temperature between 15°C and 25°C, away from direct light.

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