Packaging
10 mL vials
Compounds
Each device contains 1.38 grams of natural progesterone.
Mechanism of the Effect
The CIDR (Controlled Internal Drug Release) device is made of silicone impregnated with natural progesterone, which releases a fixed daily dose of 23 mg of progesterone. The sheep CIDR contains 330 mg of progesterone and is inserted into the vagina using a special applicator. Progesterone is a natural hormone secreted by the corpus luteum of the ovary, which forms from the remaining follicle after ovulation and maintains pregnancy.
When progesterone is administered artificially, it tricks the body’s control mechanisms, causing the female animal to feel pregnant, thus preventing estrus and ovulation. Once the progesterone source is completely removed or depleted, the body senses that pregnancy has ended and initiates ovulation after a specified period. These substances mimic the function of the ovarian corpus luteum.
Use case
Estrus synchronization control
Ovulation during and outside the breeding season
Increased twinning rate
The amount and how to use
Each animal uses one intravaginal device (CIDR).
Usage Instructions:
Insert the device into the animal’s (cow or sheep) vagina in a sterile manner using gloves.
The device typically remains in the vagina for 7 to 14 days to gradually release progesterone.
After the designated period, carefully remove the device.
If necessary, complementary or hormonal medications (such as Paratagal or gonadotropin) may be prescribed alongside this device.
Caution
Before use, the animal must be healthy and free from any vaginal infections or inflammation.
Insert the device with sterile gloves to prevent contamination.
If the animal shows sensitivity or adverse reactions to progesterone, discontinue use and inform the veterinarian.
In case of inflammation, abnormal discharge, or fever after insertion, consult a veterinarian immediately.
Do not leave the device in the vagina longer than the prescribed duration to prevent infection.
Use during pregnancy only with a veterinarian’s prescription and in specific cases.
Drug interference
Concurrent use with other progestin or estrogen hormones should be done cautiously and under veterinary supervision to avoid interaction effects.
Non-steroidal anti-inflammatory drugs (NSAIDs) may affect the physiological response to progesterone.
Concurrent use with drugs that alter hormonal balance (e.g., gonadotropins) must be strictly followed as per the veterinarian’s instructions.
Concurrent use with antibiotics typically does not cause interactions, but consultation is always recommended before combining medications.
Always consult a veterinarian before starting or combining any medication with the CIDR.
Maintenance conditions
Store at 25-30°C and keep out of reach of children.
