Packaging
10 mL vial
Compounds
Estradiol Valerate
Mechanism of the Effect
Estradiol benzoate induces the onset of estrous signs in females and has a stimulatory effect on the growth of the uterus and mammary glands, increases uterine mucus secretion, causes cervical dilation, and enhances uterine sensitivity to oxytocin. At high doses, it inhibits the release of GnRH and milk secretion, while at low doses, it stimulates follicular growth by increasing the release of FSH.
Use case
Cattle: For luteal insufficiency and induction of estrus, mammary fixation, fetal maceration, retained placenta, metritis, and pyometra.
Horse: For mild estrus without ovulation and induction of parturition.
Sheep and goats: For anestrus and mild estrus.
Dog: For abortion induction and urinary tract infections.
Additionally, in male dogs and cats, it is used to increase sexual desire, and to treat prostatic hyperplasia and swelling.
The amount and how to use
Vutastrol® can be administered via intramuscular or subcutaneous injection.
Cattle: For luteal insufficiency and estrus induction, 5 mg (preferably combined with chorionic gonadotropin). For mammary fixation, fetal maceration, and retained placenta, 5–10 mg administered 2–3 times per week. For metritis and pyometra, 20–25 mg simultaneously with oxytocin (50 IU), with treatment repeated after one week.
Horse: For mild estrus without ovulation, 5–10 mg; for induction of parturition, 5 mg administered 12–24 hours before oxytocin injection.
Sheep and goats: For anestrus, 1.5 mg with treatment repeated after two days; for mild estrus, 0.5–1 mg.
Dog: For abortion induction, 2–5 mg injected once 2–5 days after mating. For anal adenoma, increased sexual desire, prostatic hyperplasia, and swelling, 1–2 mg with repetition after one month if necessary.
Cat: For abortion induction, 0.125–0.25 mg administered intramuscularly 3–5 days after mating.
Caution
Use only under veterinary supervision and at the prescribed dose.
Should not be used in pregnant animals except in special cases.
Avoid injection into infected or inflamed sites.
Use with caution in animals with a history of sensitivity to estrogens.
Prolonged or excessive use may cause hormonal disturbances and uterine tumors.
In case of allergic reactions, discontinue use and monitor the animal.
Store the medication in a cool, dry place away from direct ligh
Drug interference
Concurrent use with other hormonal drugs (such as progesterone and gonadotropins) may alter the effect of estradiol.
Anticoagulant drugs may interact with estrogens and increase the risk of bleeding.
Corticosteroids can reduce the hormonal effects of estrogens.
Concurrent use with non-steroidal anti-inflammatory drugs (NSAIDs) should be done with caution.
Always consult a veterinarian before using any other medication concurrently with Vutastrol®.
Maintenance conditions
Store below 25°C, protected from light. Protect the drug from freezing.
